MeSince® supports free email service such as Outlook(hotmail), QQ, 163, etc., and supports business email too. Exchange, SMTP(SSL), POP3(SSL) and IMAP(SSL) are supported. It's configured to mail server that are securely connected though SSL by default. Some may require to manually opening the SMTP/POP/IMAP.
MeSince maintains preset parameters for most popular mail server(but not all), so if it ask you to enter the correct mail sever parameter, please enter the correct ones.